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Furthermore, these analogues have the ability to stimulate natriuresis by inhibiting sodium reabsorption by decreasing the activity of sodium-hydrogen exchanger 3 (NHE3), resulting in a reduction in blood pressure in patients with diabetes (40, 46)

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Patients treated with these medications can develop several skin reactions, including injection-site reactions, hypersensitivity responses, pruritus, rashes, and immune-mediated skin disorders such as psoriasis (Pso) and hidradenitis suppurativa (HS) [14,17,18,19,20]